kanen-serotonin-2021

To determine the relevance of serotoninergic signaling for learning and cognitive flexibility. Assessing the effects of serotonin depletion on reversal learning.

Kanen et al. compared groups of people with and without serotonin-depletion in two reversal-learning tasks. The first was an operant-condiditioning task, and the second a pavlovian-conditioning task.

The authors found that depleted groups performed substantially worse on the reversal phase. Additionally, they found that depleted groups performed better on operant conditioning.