frick-dual-2015

Frick et al. examine reversal-learning under the effects of various serotoninergic medications.

They find that

• 10 mg/kg fluoxetine (reuptake inhibitor) impairs acquisition and improves reversal.
• 10 mg/kg tianepentine (reuptake enhancer) improved acquisition and impaired reversal
• 10 mg/kg busprione (5HT1A agonist) impaired acquisiion, no effect on reversal
• 1 mg/kg risperidone (5HT2A antagonist) impaired acquisition and improved reversal
• 2 mg/kg ondansetron (5HT3 antagonist) impaired acquisition and improved reversal